NEws NEws dnfsdd8a32 Registered user 100 Points
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Full name: http://www.tnnchemical.com/pharmaceutical-raw-materials/
Location: http://www.tnnchemical.com/pharmaceutical-raw-materials/
Website: http://www.tnnchemical.com/pharmaceutical-raw-materials/
About: Rapid and reliable identification and validation of incoming raw materials is

critical for drug manufacturing
</h1>
<p>
    Impurities and adulterants in <a

href="http://www.tnnchemical.com/pharmaceutical-raw-materials/" target="_self">raw

materials</a> pose potential health threats when present in the manufacturing of

pharmaceutical APIs and drug products. These same impurities and adulterants may

also result in lower production yields and greater needs for product purification.

Thus, their identification and quantification within incoming raw material play an

important role in the pharma industry, ensuring product safety &amp; quality, and

an overall smooth and cost-efficient manufacturing process.
</p>
<p>
    Bruker offers a complete portfolio of analytical systems for quick and

accurate identification of raw materials.
</p>
<p>
    X-ray fluorescence (XRF) is a reliable, precise, and accurate technique with

the potential to analyze inorganic impurities at ppm or even sub-ppm level in many

types of raw materials used in the pharma industry. XRF is also ideal for quick

identification of certain substances, such as the differentiation of KCl and NaCl.

Modern high-end laboratory energy-dispersive   XRF spectrometers   allow for high

throughput, are easy to operate, and comply with applicable data management

regulations (e.g. 21 CFR Part 11). Portable XRF units can be used for a quick

assessment of a new delivery upon arrival.
</p>
<p>
    Key advantages of XRF compared to more classical wet chemical techniques are

the fast and simple sample preparation, the ease-of-use, and the low operation

costs (no toxic/expensive chemicals/gases required!
</p>
<p>
    Uniquely, XRD directly probes the atomic and molecular arrangements in solid

forms. X-ray powder diffraction, therefore, enables detection, identification, and

quantification of crystalline and amorphous APIs, excipients, and other any

materials via fingerprinting. Raw materials can be quickly screened to control

purity, crystallinity, and polymorphism as well as absolute phase abundance in

mixtures.
</p>
<p>
    FT-NIR spectroscopy   via fiber optic probes is rapidly becoming a standard

method of accomplishing this crucial material validation, providing unprecedented

speed and flexibility for the identification of both solid materials and liquids.
</p>
<p>
    Both   MPA   II   and   MATRIX-F   FT-NIR spectrometers can be equipped with

fiber optic probes for direct analysis of raw materials in their containers.

Complete identification software guides the user through the library creation

process and provides single-click identification even at the loading dock. The   

MATRIX-F   system comes with a NEMA rated enclosure enabling it to withstand the

toughest plant environments.
</p>
<p>
    Incoming goods inspection and quality control using   FT-IR spectroscopy   are

mainly performed using the so-called ATR (Attenuated Total Reflection) technique.

It allows measuring IR spectra of almost all types of liquid, solid, and paste-

like samples within some seconds. For identity control, the sample spectrum is

compared against the spectrum of a reference substance.
</p>
<p>
    The growing demand for   portable Raman   systems for material verification is

constituted in the vast capabilities of this spectroscopic technique. High

selective information content and no need for sample preparation combined with the

capability to probe materials directly through transparent packaging material

often make Raman spectroscopy as the method of choice.
</p>
<p>
    Bruker developed the   BRAVO   to overcome the limitations of handheld Raman

spectroscopy like fluorescence or safety issues. As a class 1M laser product,

BRAVO combines maximum user safety with the utmost ease of use, of course fully

compliant to regulations like CFR 21 Part 11. BRAVO is the lab in your hands for

material verification in the pharmaceutical industry.
</p>
<p>
    NMR   on the other hand, being a structural rich technique and inherently

quantitative, offers the advantage of testing the identity of raw materials and

their quantification in the same experiment, which can take less than 1 minute.

Should   impurities   be detected, NMR and MS are the techniques of choice to

elucidate the unknows, providing go- or no-go information.
</p>
<h2>
    The Benefits of Plant Extracts for Human Health
</h2>
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